A Membrane Microcontactor as a Tool for Sample Pre-treatment of Pharmaceutical Compounds
نویسندگان
چکیده
A membrane microcontactor is presented that allows sample pre-treatment by means of extraction and operates in parallel flow mode, hence avoiding an emulsification and compulsory phase separation step. The extraction kinetic behaviour of the device was first evaluated by extraction of a drug candidate, proving equilibrium is reached within 10 min. Next the device was evaluated under more challenging working conditions, a homogenized mouse kidney sample containing the drug candidate was cleaned and characterized by HPLC. The system has the potential to be operated in a continuous fashion making it appealing to be implemented in screening or high throughput applications.
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